CBD and the Liver



For those of you that have been closely following my blog you will already know that recently my ALP (alkaline phosphatase) test results were slightly elevated. If you haven’t read that post, you can click here.  Hi, CEO Olivia here, today I’m barking about CBD & the liver.

Back in March  2020 the FDA & the media were giving CBD some pawsitively negative coverage alleging that CBD raised liver enzymes.  The study they based this misinformation on involved a synthetic CBD isolate called Epidiolex. It’s made by a pharmaceutical company called GW Pharmaceuticals, who want to monopolize all medical cannabis medications. The dosages used in this study were pawsitively, dog gone, ridiculously high even for humans yet they were administered to mice. Also, because Epidiolex is synthetic, there were no other cannabinoids present, therefore there was no entourage effect.

But lets look at naturally derived CBD oil. Studies by the American National Institute of Health reported way back in 2013 that CBD had therapeutic potential for many diseases.

Time for a quick refresher, if you have a spine, you have a endocannabinoid system with cannabinoid receptors. There are two subtypes called CBD1 & you guessed it, CBD2.

In the liver & kidneys, if CBD1 receptors becomes overstimulated they weaken the CBD2 receptors, throwing both out of balance. This can lead to serious health issues. CBD1 is what’s called profibrotic which means it encourages fibrous connective tissue in response to an injury. CBD2 is the opposite, it’s antifibrotic meaning it impedes fibrosis & acts as a blood thinner. You can see how it’s impawtant that they work together in harmony.

Taking CBD from Cannabis/hemp has been shown to fine tune the CBD1 & CBD2 receptors & bring them back into balance if needed. Research suggests that taking CBD regularly can maintain this balance.

There have been published studies that have shown that CBD is beneficial to the liver & helps keep it healthy. In one study, when administered to rats who were intentionally given liver disease, the CBD killed off cells which cause scar tissue within the liver. Please note that we here at KTFGD’s are against using animals for lab testing.

Research is ongoing but time after time, results show that not only that there is no evidence of CBD oil causing damage to the liver, quite the opposite seems to be true. CBD appears to help maintain a healthy functioning liver.

I have continued taking my full spectrum CBD oil. I am going to dig deeper into that soon. huMom has observed no adverse affects & I’m 170 days seizure free today. If you haven’t, please sniff out my blog series exploring CBD, I walk you through from the plant in the field to the finished product. It’s benefits & how to avoid being sold ‘snake oil’ are also dogsplained. Here are the links:

Part 1 – CBDs, Cannabinoids, Endocannabinoids & Canines

Part 2 – What is Cannabis?

Part 3 – How CBD Is Extracted?

Part 4 – CBD Full Spectrum, Broad Spectrum & Isolates

Part 5 – CBD Oils & Tinctures, What’s In the Bottle?

Part 6 – Understanding a CBD Certificate of Analysis

Part 7 – CBD Oils, What Should Be On the Label?

Part 8 – CBD Micro Dosing Explained

Part 9 – CBD & the Liver

Have a pawsome week.

CEO Olivia

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The Bile Acid Test



Today, as promised, I’m explaining what a bile acid test is because I will be getting one in a few months. There are two blood tests that can help determine how healthy my liver is. One is called a liver enzyme level & the other is a bile acid test. The liver enzyme test can indicate the degree of inflammation or damage. A bile acid test measures how the liver functions & if it is working properly. A healthy liver will recycle bile acids, a damaged liver wont. Doing a bile acid test will reveal if enough healthy cells are present, if the blood supply to the liver is adequate & if bile moving through & out of the liver properly.

The liver secretes bile which is needed for proper digestion because it breaks down fats. During digestion bile acids are released by the gallbladder where they are stored &  get absorbed by the intestine, then the bloodstream. If the liver is functioning properly, the bile acids are then removed from the bloodstream & returned to the gallbladder until they are needed again. This is called Enterohepatic Circulation.

I’m having this test done because the medications I have to take daily are known to be stressful on the liver. More so over time & I am getting older. When I have my test done, huMom says I’ll have to fast, which is pawsitively displeasing to know. Not only that, I can’t even smell food because we don’t want my tummy waking up. My good vet will take a blood sample & then my good Vet or Vet Tech will feed me a small fatty meal . Two hours later, my vet will take a second blood sample.

The two blood samples will be compared to show before & after meal levels of bile acids. If they show blood levels of bile acids that are high, this means that my liver isn’t doing its job as well as it should & huMom will work with my vet to get my liver healthier. However, we are staying pawsitive & hoping for a low bile acid count.

huMom understands, this is part of living with canine epilepsy. My medications are life saving but they are harsh on my body. Which reminds me, today I’m 163 days seizure free. I’ll be pup-dating you soon on huMom’s thoughts about my CBD oil & I’ll share what I’ve sniffed out about what, if any effect they have on the liver.

CEO Olivia

More Tests for Our CEO Olivia


After talking to my Vet, we decided to book another ALP (alkaline phosphatase) test in three months.  ALP is an enzyme that helps break down proteins. The body uses ALP for a wide range of processes, & it plays a pawticularly important role in liver function. We have also included a Bile Acid test which will give us more information about how my liver is functioning.

Hi everyone, CEO Olivia here.  Many of you know that I live with idiopathic canine epilepsy, being diagnosed when I was just 1 year old. I have to take several AEDs (anti epilepsy drugs) daily.  One of them is called phenobarbital. Long term use of this drug can negatively effect the liver.

Recently, my bloodwork showed a slight elevation in my APL levels.  My vet isn’t overly concerned by the number, she reminded huMom that Phenobarbital can turn on the production of ALP.  Phenobarbital can benignly cause an elevated ALP, but as I mentioned it can also cause liver damage over time. Because of this we have dogcided to more testing so we can differentiate between a benign or toxic liver change. An increase ALP can also signal a gallbladder or bile problem or a tumor in the liver.  More testing will help huMom understand what is going on so we can move forward proactively. We even discussed pawtentionally meeting with my neurologist if necessary.

In the following weeks I’ll dogsplain what a Bile Acid Test is, how it works & why I’m having one done. I’ll also be barking about something called Euthyroid Syndrome which can be caused by phenobarbital. I also will be addressing those who have concerns about how CBD oil can effect the liver.

CEO Olivia